Advanced Course

Biocatalysis and Protein Engineering

Course description

The Advanced Course Biocatalysis aims to familiarize participants with the integrated, interdisciplinary approach required to utilize the catalytic potential of enzymes and whole cells for the production of useful compounds. Organic chemists, enzymologists, microbiologists and (bio)chemical engineers from the faculty staff of Delft University of Technology and other universities, together with invited international experts from industry, will offer a selection of theory and practice. In this way, the course will provide an intensive and in-depth treatment of the state of the art and the necessary link between fundamental knowledge and practical applications in industrial scale processes. This course was held for the 15th time in 2016.

Note: A limited number of fellowships is available for PhD students (reduced fee).

9-13 April 2018

Delft University of Technology, the Netherlands

THE COURSE

Advanced Course Biocatalysis and Protein Engineering

For a better understanding of the lectures and to stimulate active participation by those attending, this intensive one-week course combines lectures with practical demonstrations. The course will be given in English.

Lectures

During the lectures attention will be paid to the following questions:

  •  When is biocatalysis the preferred method?
  • Which type of biocatalysis should be used?
  • How to obtain / improve this biocatalyst?
  • Which reaction types can be carried out?
  • How to perform and monitor the conversion?
  • How to optimize the reaction conditions?

Who should attend?

This Advanced Course is aimed at professionals (MSc, PhD or equivalent experience) in biochemical engineering, organic chemistry, fermentation technology, biochemistry or microbiology with a basic working knowledge of the other disciplines. The course is primarily aimed at those already employed in industry who wish to update their theoretical knowledge and practical insight in this field. In addition, this Advanced Course is an option in the two-year postgraduate programs of Delft University of Technology.

PROGRAMME

Programme 2018 will be published asap

Monday, 4 April 2016
08.45 Registration
09.00 Outlook of the course Isabel Arends
09.15 Keynote lecture: The future of Biocatalysis Isabel Arends
10.30 Enzyme-catalysed synthesis of C-C bonds Ulf Hanefeld
11.45 Immobilisation of biocatalysts Roger Sheldon
14.45 From natural environment to biocatalyst Gerard Muyzer
16.00 Engineering nature’s enzyme repertoire for food, pharma and biofuels René de Jong
17.00 Social drink and buffet
Tuesday, 5 April 2016
09.00 Themes of the day
09.15 Biocatalysis and sustainability John Woodley
10.45 Case study: Reactions of serine hydrolases Ulf Hanefeld
14.45 Reactions with proteases Timo Nuijens
16.00 Principles of enantioselection: mathematics and applications Adrie Straathof
17.00 Reaction engineering: optimizing the medium for enzymatic conversions Adrie Straathof
Wednesday, 6 April 2016
09.00 Themes of the day
09.15 Protein engineering Dick Janssen
10.30 Genomic databases, bioinformatics and biocatalysis Dick Janssen
11.30 Directed evolution of enzymes Uwe Bornscheuer
14.15 Biocatalysis – A tool for sustainable production of ester-based surfactants Oliver Thum
15.30 Workshop
Enzyme visualisation / bioinformatics (basic / advanced)
Linda Otten
 
Thursday, 7 April 2016
09.00 Themes of the day
09.15 From biotransformation towards industrial process Adrie Straathof
11.30 Non-aqueous biocatalysis Ulf Hanefeld
13.45 Enzymes in food technology Stuart West
15.15 Development of efficient enzymes using the fungal C1-technology platform Sandra Hinz
18.00 Course dinner – downtown Delft
Friday, 8 April 2016
09.00 Themes of the day
09.15 Fundamentals and application of BioRedoxCatalysis Stephan Lütz
11.15 Biocatalytic oxidation and oxyfunctionalization reactions Frank Hollmann
14.00 Selection and development of biocatalysts for the preparation of fine chemicals Bernhard Hauer
15.00 An industrial perspective on biocatalysis Andreas Taglieber
16.00 Evaluation of the course and farewell drink Ulf Hanefeld
LOCATION

The course will be held at:

Faculty of Applied Sciences (building 58)
Department of Biotechnology
Delft University of Technology
Van der Maasweg 9
2629 HZ Delft
The Netherlands
P +31 (0)15 278 1922
F +31 (0)15 278 2355
E BiotechDelft@tudelft.nl


FEE

The course fee is:

The course fee is € 2.500 in case the booking is made before 12 February 2018 or  € 2.750 in case the booking is made after this date. In the event of cancellation before 26 February 2018, a full refund will be granted, after this date, a 25% fee charge will be made. To facilitate enrollment of young PhD-students, a limited number of fellowships is available. The course fee with fellowship is € 1250.-. To apply, please include a copy of your registration as a PhD-student from your university.

The fee includes course materials, lunches, the buffet on Monday, April 9th and the course dinner on Thursday, April 12th. The fee does not cover other meals and lodging.

When the number of participants is too low to have a fruitful course, the Institute BioTech Delft will cancel the event no later than five weeks before the start of the course. The course fee will be reimbursed within three weeks after cancellation. In case a speaker will not be able to present his/her lecture, due to unforeseen circumstances, BioTech Delft will arrange an equivalent replacement.

Hotel accommodation can be arranged at your request. Preparatory texts will be sent after receipt of the course fee. The complete course book will be supplied at the start of the course.

Course fees can be paid by bank transfer or credit card (we are required to charge extra costs for this option; please contact us). TU Delft employees can use their internal (project) code. Customers are requested to pay the course fee within 30 days after the invoice date, but at the latest six weeks before the course starts. In case of payment before this date, the reduced course fee applies. After this date, we charge the full course fee. The course fees need to be on our bank account before the course starts.

DOWNLOADS
LECTURERS

Course board

Prof. Isabel Arends

Isabel Arends obtained her MSc and PhD degrees in organic chemistry at Leiden University. Currently she is head of the TU Delft Department of Biotechnology and professor of Biocatalysis and Organic Chemistry in this department. Her research focuses on the development of catalysts for green products and medicines, with a focus on development and application of enzymes. She studies oxidative enzymes, as well as metal hybrid proteins and explores their potential for sustainable production of epoxides, alcohols and ketones. Prof. Arends has over 150 scientific publications, and has supervised more than 30 PhD students and postdocs over the last 10 years. In addition, she is vice-president of the BSDL foundation (Stichting Biotechnological Sciences Delft Leiden) and member of the board of Technology Foundation STW.

Prof. Ulf Hanefeld

Ulf Hanefeld is a full professor in Biocatalysis at Delft University of Technology. He was born in Köln, Germany, and grew up in then (West) Berlin and London. In 1993 he received his PhD from the Georg-August-Universität zu Göttingen, having performed the research both in Göttingen (Prof. H. Laatsch) and Seattle (Prof. H. G. Floss). After postdoctoral years with Prof. C. W. Rees (Imperial College London), Prof. J. Staunton (Cambridge) and Prof.  J. J. Heijnen and Dr. A. J. J. Straathof (TU Delft), he received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW). He rose through the ranks at the Technische Universiteit Delft and his research in Delft focuses on enzymes and enzyme immobilisation for organic synthesis.

Faculty staff

Dr. Frank Hollmann

After his MSc in Chemistry at the University of Bonn (Germany), Frank Hollmann completed his PhD thesis at the Swiss Federal Institute of Technology (ETH Zurich), Switzerland. After working as a postdoc at the Max-Planck-Institute for Coal Research (Germany) and as R&D manager at Evonik Industries (Germany ), he became an Assistant Professor at the Delft University of Technology in 2008. His main research interests are the application of oxidoreductases for organic synthesis and green chemistry using enzymes.

Dr. Adrie Straathof

Adrie Straathof is Associate Professor in the Bioprocess Engineering group of the Department of Biotechnology of the Delft University of Technology. Previously he was Assistant Professor and Ph.D. student in the Biokinetics and Organic Chemistry groups, respectively, at the same university. He was visiting professor at UNICAMP, Campinas (Brazil), and at ETH Zurich (Switzerland). He was programme leader of the Bulk Chemicals program in the B-BASIC (biobased sustainable industrial chemicals) consortium. His research interests are (a) enzymatic and microbial manufacturing of fine chemicals, bulk chemicals, and biofuels; (b) in-situ  bioproduct recovery using crystallization, adsorption, extraction, membrane permeation; (c) model based and experimental bioprocess integration; and (d) kinetics and thermodynamics for biotechnological processes.

Guest lecturers

Prof. Uwe Bornscheuer

Greifswald University, Institute of Biochemistry, Greifswald, Germany

Dr. Bernhard Hauer

University Stuttgart, Dept. of Biological Engineering, Stuttgart, Germany

Dr. Sandra Hinz

DuPont Industrial Biosciences, Wageningen, the Netherlands

Prof. Dick Janssen

University of Groningen, Dept. of Biochemistry, Groningen, the Netherlands

Dr. René de Jong

DSM Biotechnology Center, Delft, the Netherlands

Dr. Stephan Lütz

Novartis Pharma AG, Basel, Switzerland

Prof. Gerard Muyzer

Gerard Muyzer started his scientific career in molecular paleontology using antibodies to study the macromolecular remains in fossil shells and dinosaur bones. Inspired by the work of the American scientists Norman Pace and David Stahl, he changed his research interests from dinosaurs to microbes. Prof. Muyzer worked at the Max-Planck-Institute for Marine Microbiology, the Royal Netherlands Institute for Sea Research, and Delft University of Technology. Currently he is a full Professor in Microbial Systems Ecology at the University of Amsterdam. In 2012 he received a prestigious ERC Advanced Grant on a project entitled The Paradox of Sulfur Bacteria in Soda Lakes, in which he will try to obtain a comprehensive understanding of the diversity and ecophysiology of sulfur bacteria in soda lakes, their niche differentiation and the molecular mechanisms by which they adapt to the extreme halo-alkaline conditions.

Dr. Timo Nuijens

Enzypep, Geleen, the Netherlands

Prof. Roger Sheldon

CLEA Technologies B.V., Delft, the Netherlands

Dr. Andreas Taglieber

Firmenich SA, Geneva, Switzerland

Dr. Oliver Thum

Evonik Goldschmidt GmbH, Essen, Germany

Dr. Stuart West

Biocatalysts Ltd., Wales, United Kingdom

Prof. John Woodley

DTU Technical University Denmark, Lyngby, Denmark

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