The Advanced Course Biocatalysis aims to familiarize participants with the integrated, interdisciplinary approach required to utilize the catalytic potential of enzymes and whole cells for the production of useful compounds. Organic chemists, enzymologists, microbiologists and (bio)chemical engineers from the faculty staff of Delft University of Technology and other universities, together with invited international experts from industry, will offer a selection of theory and practice. In this way, the course will provide an intensive and in-depth treatment of the state of the art and the necessary link between fundamental knowledge and practical applications in industrial scale processes.
Note: A limited number of fellowships is available for PhD students (reduced fee).
Advanced Course Biocatalysis and Protein Engineering
For a better understanding of the lectures and to stimulate active participation by those attending, this intensive one-week course combines lectures with practical demonstrations. The course will be given in English.
During the lectures attention will be paid to the following questions:
- When is biocatalysis the preferred method?
- Which type of biocatalysis should be used?
- How to obtain / improve this biocatalyst?
- Which reaction types can be carried out?
- How to perform and monitor the conversion?
- How to optimize the reaction conditions?
The course (including preparatory materials) is valued 40 hours of work.
Who should attend?
This Advanced Course is aimed at professionals (MSc, PhD or equivalent experience) in biochemical engineering, organic chemistry, fermentation technology, biochemistry or microbiology with a basic working knowledge of the other disciplines. The course is primarily aimed at those already employed in industry who wish to update their theoretical knowledge and practical insight in this field. In addition, this Advanced Course is an option in the two-year postgraduate programs of Delft University of Technology.
Program of 2020
|Monday, 20 April 2020|
|09.00||Short introduction of how to use the Surface||Vincent Renken|
|09.10||Outlook of the course||Ulf Hanefeld|
|09.30||From natural environment to biocatalyst||Gerard Muyzer|
|10.45||Industrial Applications of Biocatalysis for Antibiotic and Pharmaceutical synthesis||Burghard König|
|12.00||Immobilisation of biocatalysts||Roger Sheldon|
|13.45||Continuation: Immobilization of biocatalysts||Roger Sheldon|
|14.45||Economics and Implementation of Biocatalytic Processes||John Woodley|
|16.00||Engineering nature’s enzyme repertoire for food, pharma and biofuels||René de Jong|
|17.30||Social drink and buffet|
|Tuesday, 21 April 2020|
|09.00||Themes of the day|
|09.15||Rational design and directed evolution of enzymes||Uwe Bornscheuer|
|10.45||Case study: Reactions of serine hydrolases||Ulf Hanefeld|
|13.30||Team presentation of the case study|
|14.45||Non-aqueous biocatalysis||Ulf Hanefeld|
|15.45||Principles and applications of enantioselection||Caroline Paul|
|16.45||Reaction engineering: optimizing the medium for enzymatic conversions||Caroline Paul|
|18.00||End of day|
|Wednesday, 22 April 2020|
|09.00||Themes of the day|
|09.15||Protein engineering: enzyme stability – enzyme specificity – optimisation of biocatalytic characteristic||Dick Janssen|
|10.30||Genomic databases, bioinformatics and biocatalysis||Dick Janssen|
|11.30||Enzyme-catalysed synthesis of C-C bonds: Hydroxynitrile lyase/Oxynitrilase||Ulf Hanefeld|
|14.15||Biocatalysis – A tool for sustainable production of ester-based surfactants||Oliver Thum|
|15.30||Computer practical: Pymol||Peter Leon Hagedoorn|
|18.00||End of day|
|Thursday, 23 April 2020|
|09.00||Themes of the day|
|09.15||From biotransformation towards industrial process||Adrie Straathof|
|11.30||Industrial biocatalysis in food and pharma||Alessandra Basso|
|13.45||An industrial perspective from the world of flavors and fragrances||Andreas Taglieber|
|15.00||Enzymes for lignocellulose degradation||Mirjam Kabel|
|Friday, 24 April 2020|
|09.00||Themes of the day|
|09.15||Fundamentals and application of BioRedoxCatalysis||Stephan Lütz|
|11.15||Biocatalytic oxidation and oxyfunctionalization reactions||Stephan Lütz|
|13.15||Biocatalysts for the synthesis of chiral amines||Bernhard Hauer|
|14.30||Novel enzymes||Frank Hollmann|
|15.30||Evaluation of the course||Frank Hollmann|
The course will be held at:
Faculty of Applied Sciences (building 58)
Department of Biotechnology
Delft University of Technology
Van der Maasweg 9
2629 HZ Delft
P +31 (0)15 278 1922
F +31 (0)15 278 2355
Deadline for registration is 30 March 2020
The course fee is:
*To be eligible for the reduced early bird fee you need to register before 10th of February 2020. If this date is exceeded, the regular fee applies.
**A limited number of fellowships is available for PhD students. To apply, please include a copy of your registration as a PhD student from your university.
The fee includes course materials, lunches and the buffets and the course dinners as indicated on the program. The fee does not cover other meals or lodging. Hotel accommodation can be arranged at your request.
The course fee is preferably paid by bank transfer. Payment by PayPal is possible. TU Delft employees can use their internal (project) code.
Preparatory texts will be sent one month before start of the course and after receipt of the course fee. The complete set of course books will be supplied at the start of the course.
In the event of your cancellation before 24th of February 2020, a full refund will be granted. After this date, a 25% fee charge can be made.
Delay of payment past the final deadline as indicated on the invoice may result in cancellation of entry to the course. Re-entry is only possible in case of vacancies and the regular fee will be applied. Payment terms and deadlines will be indicated on the invoice and/or provided in an e-mail after registration, but the course fee should always be paid before the start of the course.
When the number of participants is too low to have a fruitful course, the Institute BioTech Delft will cancel the event no later than six weeks before the start of the course. The course fee will be reimbursed within three weeks after cancellation. In case a speaker will not be able to present his/her lecture, due to unforeseen circumstances, BioTech Delft will arrange an equivalent replacement.
Prof. Isabel Arends
Isabel Arends obtained her MSc and PhD degrees in organic chemistry at Leiden University. Currently she is head of the TU Delft Department of Biotechnology and professor of Biocatalysis and Organic Chemistry in this department. Her research focuses on the development of catalysts for green products and medicines, with a focus on development and application of enzymes. She studies oxidative enzymes, as well as metal hybrid proteins and explores their potential for sustainable production of epoxides, alcohols and ketones. Prof. Arends has over 150 scientific publications, and has supervised more than 30 PhD students and postdocs over the last 10 years. In addition, she is vice-president of the BSDL foundation (Stichting Biotechnological Sciences Delft Leiden) and member of the board of Technology Foundation STW.
Prof. Ulf Hanefeld
Ulf Hanefeld is a full professor in Biocatalysis at Delft University of Technology. He was born in Köln, Germany, and grew up in then (West) Berlin and London. In 1993 he received his PhD from the Georg-August-Universität zu Göttingen, having performed the research both in Göttingen (Prof. H. Laatsch) and Seattle (Prof. H. G. Floss). After postdoctoral years with Prof. C. W. Rees (Imperial College London), Prof. J. Staunton (Cambridge) and Prof. J. J. Heijnen and Dr. A. J. J. Straathof (TU Delft), he received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW). He rose through the ranks at the Technische Universiteit Delft and his research in Delft focuses on enzymes and enzyme immobilisation for organic synthesis.
Dr. Frank Hollmann
After his MSc in Chemistry at the University of Bonn (Germany), Frank Hollmann completed his PhD thesis at the Swiss Federal Institute of Technology (ETH Zurich), Switzerland. After working as a postdoc at the Max-Planck-Institute for Coal Research (Germany) and as R&D manager at Evonik Industries (Germany ), he became an Assistant Professor at the Delft University of Technology in 2008. His main research interests are the application of oxidoreductases for organic synthesis and green chemistry using enzymes.
Dr. Adrie Straathof
Adrie Straathof is Associate Professor in the Bioprocess Engineering group of the Department of Biotechnology of the Delft University of Technology. Previously he was Assistant Professor and Ph.D. student in the Biokinetics and Organic Chemistry groups, respectively, at the same university. He was visiting professor at UNICAMP, Campinas (Brazil), and at ETH Zurich (Switzerland). He was programme leader of the Bulk Chemicals program in the B-BASIC (biobased sustainable industrial chemicals) consortium. His research interests are (a) enzymatic and microbial manufacturing of fine chemicals, bulk chemicals, and biofuels; (b) in-situ bioproduct recovery using crystallization, adsorption, extraction, membrane permeation; (c) model based and experimental bioprocess integration; and (d) kinetics and thermodynamics for biotechnological processes.
Dr. Allesandra Basso
Purolite, Cardiff, United Kingdom
Prof. Uwe Bornscheuer
Greifswald University, Institute of Biochemistry, Greifswald, Germany
Dr. Bernhard Hauer
University Stuttgart, Dept. of Biological Engineering, Stuttgart, Germany
Prof. Dick Janssen
University of Groningen, Dept. of Biochemistry, Groningen, the Netherlands
Dr. René de Jong
DSM Biotechnology Center, Delft, the Netherlands
Dr. Burghard König
Koenig & Funk Biotech Ltd., Berlin, Germany
Prof. Dr. Stephan Lütz
TU Dortmund University, Dortmund, Germany
Prof. Gerard Muyzer
Gerard Muyzer started his scientific career in molecular paleontology using antibodies to study the macromolecular remains in fossil shells and dinosaur bones. Inspired by the work of the American scientists Norman Pace and David Stahl, he changed his research interests from dinosaurs to microbes. Prof. Muyzer worked at the Max-Planck-Institute for Marine Microbiology, the Royal Netherlands Institute for Sea Research, and Delft University of Technology. Currently he is a full Professor in Microbial Systems Ecology at the University of Amsterdam. In 2012 he received a prestigious ERC Advanced Grant on a project entitled The Paradox of Sulfur Bacteria in Soda Lakes, in which he will try to obtain a comprehensive understanding of the diversity and ecophysiology of sulfur bacteria in soda lakes, their niche differentiation and the molecular mechanisms by which they adapt to the extreme halo-alkaline conditions.
Prof. Roger Sheldon
CLEA Technologies B.V., Delft, the Netherlands
Dr. Andreas Taglieber
Firmenich SA, Geneva, Switzerland
Dr. Oliver Thum
Evonik Goldschmidt GmbH, Essen, Germany
Prof. John Woodley
DTU Technical University Denmark, Lyngby, Denmark
Prof. Peter Leon Hagedoorn
Delft University of Technology, Delft, the Netherlands